Endocrine Abstracts

Extra-cellular nicotinamide phosphoribosyltransferase (eNAMPT; also referred to as visfatin/PBEF) concentrations are elevated in serum of patients with type 2 diabetes (T2D). However, the relationship between abnormally elevated serum eNAMPT and the pathophysiology of T2D is unclear. eNAMPT circulates in functionally and structurally distinct monomer and dimer forms. eNAMPT-dimer exerts NAD-biosynthetic activity. The role of eNAMPT-monomer is unclear but may exert NAD-independ...